Magnesium Sulfate as a medication is used to treat and prevent low blood magnesium and seizures in women with eclampsia. It is also used in the treatment of torsades de pointes, severe asthma exacerbations, constipation, and barium poisoning. Magnesium sulfate is a common mineral pharmaceutical preparation of magnesium, commonly known as Epsom salt, used both externally and internally. Magnesium sulfate is highly water-soluble and solubility is inhibited with lipids typically used in lotions. Lotions often employ the use of emulsions or suspensions to include both oil and water-soluble ingredients. Hence, magnesium sulfate in a lotion may not be as freely available to migrate to the skin nor to be absorbed through the skin, hence both studies may properly suggest absorption or lack thereof as a function of the carrier (in a water solution vs. in an oil emulsion/suspension). Temperature and concentration gradients may also be contributing factors to absorption.
Internal uses include:
- Oral magnesium sulfate is commonly used as a saline laxative or osmotic purgative.
- Replacement therapy for hypomagnesemia
- Magnesium sulfate is a antiarrhythmic agent for torsades de pointes in cardiac arrest under the ECC guidelines and for managing quinidine-induced arrhythmias.
- As a bronchodilator after beta-agonist and anticholinergic agents have been tried, e.g. in severe exacerbations of asthma, magnesium sulfate can be nebulized to reduce the symptoms of acute asthma. It is commonly administered via the intravenous route for the management of severe asthma attacks.
- Magnesium sulfate is effective in decreasing the risk that pre-eclampsia progresses to eclampsia. IV magnesium sulfate is used to prevent and treat seizures of eclampsia. It reduces the systolic blood pressure but doesn't alter the diastolic blood pressure, so the blood perfusion to the fetus isn't compromised. It is also commonly used for eclampsia where compared to diazepam or phenytoin it results in better outcomes.
In agriculture, magnesium sulfate is used to increase magnesium or sulfur content in the soil. It is most commonly applied to potted plants, or to magnesium-hungry crops, such as potatoes, roses, tomatoes, lemon trees, carrots, and peppers.Magnesium sulfate is used as a brewing salt in beer.
Anhydrous magnesium sulfate is commonly used as a desiccant in organic synthesis due to its affinity for water. During work-up, an organic phase is treated with anhydrous magnesium sulfate. The hydrated solid is then removed by filtration or decantation. Other inorganic sulfate salts such as sodium sulfate and calcium sulfate may be used in the same way.
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